SAB4200094
抗-PKM2 （亚型 M1） 兔抗
~1.5 mg/mL, affinity isolated antibody
别名:
抗-OIP3（OPA相互作用蛋白3）, 抗-PK3, 抗-PKM, 抗-TCB, 抗-THBP1 (甲状腺激素结合蛋白，胞质), 抗-丙酮酸激酶，肌肉（亚型 M1）
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关于此项目
NACRES:
NA.44
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IHC, IP, WB
Citations:
19
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~60 kDa
species reactivity
human, rat, mouse
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
immunocytochemistry: 5-10 μg/mL using HeLa cells, immunohistochemistry: 20-30 μg/mL using formalin-fixed paraffin embedded human colon, immunoprecipitation (IP): 2-4 μg using rat brain extract (S2 fraction), western blot: 1-2 μg/mL using mouse brain extract (S2 fraction)
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PKM2(5315)
General description
丙酮酸激酶（PK）是糖酵解的关键调节酶，具有四种同种型：L、R、M1和M2。同种型M2与癌转移有关。PK 同种型 M1 在胚胎发育过程中表达，是心脏、脑和骨骼肌组织中的主要同种型。
Application
PKM2（同种型M1）抗体还可用于：
- 免疫印迹
- 免疫沉淀
- 免疫组化
- 免疫细胞化学
Biochem/physiol Actions
丙酮酸激酶（PK） 是糖酵解途径中的关键酶。研究证明，人类癌细胞系中M2 同种型的敲低及其被 M1 同种型替代会导致 Warburg 效应的逆转，并降低在小鼠异种移植物中形成肿瘤的能力。M2 同种型Tyr105 处 的磷酸化会抑制其活性，并且在人类癌症中很常见，这表明 Tyr105 是癌细胞中促进肿瘤发生的关键代谢开关（metabolic switch）。
抗 PKM2 （同种型M1） 抗体对人类、小鼠和大鼠 PKM2（同种型M1）/PKM1 有特异性。在免疫印迹中，PKM2（同种型M1）/PKM1条带的检测被免疫肽特异性抑制。
Physical form
0.01M磷酸盐缓冲盐水溶液，pH 7.4，含有15 mM叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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低风险生物材料
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200094-200UL | 04061837914348 |