SAB4200097
Anti-NOX1 antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
别名:
Anti-GP91-2, Anti-MOX1 (mitogenic oxidase 1), Anti-NADPH oxidase 1, Anti-NOH1 (NADPH oxidase homolog 1)
产品名称
Anti-NOX1 antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~72 kDa
species reactivity
human
concentration
~1.5 mg/mL
technique(s)
immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded human colon
western blot: 0.5-1.0 μg/mL using HS68 cell extracts
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NOX1(27035)
mouse ... Nox1(237038)
rat ... Nox1(114243)
Application
Anti-NOX1 antibody produced in rabbit has been used in:
- Immunocytochemistry.
- Immunoprecipitation
- Immunoblotting.
Anti-NOX1 antibody produced in rabbit may be used in immunofluorescence and immunohistochemistry.
Biochem/physiol Actions
NADPH oxidase 1 (NOX1) requires two cytosolic regulators NADPH oxidase activator 1(NOXA1) and NADPH oxidase organizer 1 (NOXO1) as well as Ras-related C3 botulinum toxin substrate 1 (Rac1) for its activity. NOX1 and NOX2 promote neurotoxic activation of microglia suggesting that they play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS). In ALS mice deletion of either NOX1 and NOX2 gene have been shown to significantly slowed disease progression and improved survival.
NOX1 catalyzes the production of hydrogen peroxide (H2O2). Overexpression of the protein leads to the production of both superoxide and H2O2 and triggers angiogenic switch, mediating vascularization and rapid expansion of the tumor. Elevated expression of NOX1 has been observed in the brain of Parkinson′s disease (PD) patients.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
ROS production as a common mechanism of ENaC regulation by EGF, insulin, and IGF-1
Ilatovskaya DV
American Journal of Physiology. Cell Physiology, 304, C102-C111 (2013)
Anthony J Valente et al.
Cellular signalling, 25(6), 1447-1456 (2013-04-02)
We investigated the role of TRAF3 interacting protein 2 (TRAF3IP2), a redox-sensitive adapter protein and an upstream regulator of IKK and JNK in interleukin (IL)-18 induced smooth muscle cell migration, and the mechanism of its inhibition by simvastatin. The pleiotropic
Involvement of Rac1 in activation of multicomponent Nox1-and Nox3-based NADPH oxidases
Ueyama T, et al.
Molecular and cellular biology, 26(6), 2160-2174 (2006)
NADPH oxidases in Parkinson's disease: a systematic review.
Belarbi K
Mol. Neurodegener., 12 (2017)
Reactive oxygen generated by Nox1 triggers the angiogenic switch
Arbiser JL
Proceedings of the National Academy of Sciences of the USA, 99, 715-720 (2002)
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