SAB4200124
Anti-Nexilin antibody,Mouse monoclonal
clone NX-38, purified from hybridoma cell culture
别名:
Anti-NEXN, Anti-Nelin
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
NX-38, monoclonal
Application:
ICC, WB
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
NX-38, monoclonal
form
buffered aqueous solution
mol wt
antigen 80 kDa
species reactivity
mouse, human, rat
packaging
antibody small pack of 25 μL
concentration
~1 mg/mL
technique(s)
immunocytochemistry: suitable, western blot: 1-2 μg/mL using using rat brain S1 fraction extracts
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Nexn(68810)
rat ... Nexn(246172)
General description
Monoclonal Anti-Nexilin (mouse IgG2a isotype) is derived from the hybridoma NX-38 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide conjugated to KLH. Nexilin is a filamentous actin-binding protein that localizes to focal contacts. Alternative splicing of the gene yields two different isoforms namely, b-nexilin and s-nexilin.
NEXN (nexilin), a cardiac Z-disc protein is made of 675 amino acids. It is present in the heart and skeletal muscle. NEXN is mapped to human chromosome 1p31.
Application
Anti-Nexilin antibody,Mouse monoclonal may be used in immunoblotting and immunocytochemistry.
Biochem/physiol Actions
Monoclonal Anti-Nexilin recognizes human, rat, and mouse nexilin.
NEXN (nexilin) plays an important role in protecting cardiac Z-discs from forces generated within the sarcomere. Mutations in NEXN results in hypertrophic cardiomyopathy.
Nexilin may be involved in cell adhesion and migration.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
低风险生物材料
此项目有
A novel genetic variant in long non-coding RNA gene NEXN-AS1 is associated with risk of lung cancer.
Yuan H, et al.
Scientific Reports, 6, 34234-34234 (2016)
Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.
Wang H, et al.
American Journal of Human Genetics, 87(5), 687-693 (2010)
H T Law et al.
Cellular microbiology, 14(7), 1097-1108 (2012-03-03)
The bacterial pathogens Listeria monocytogenes and enteropathogenic Escherichia coli (EPEC) generate motile actin-rich structures (comet tails and pedestals) as part of their infectious processes. Nexilin, an actin-associated protein and a component of focal adhesions, has been suggested to be involved
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