Anti-ALS2CL (N-terminal region) antibody produced in rabbit

The amyotrophic lateral sclerosis 2 (ALS2) C-terminal like (ALS2CL) gene is an ALS2 homologous gene, mapped to human chromosome 3p21.31. The encoded protein is homo-dimeric and forms an heteromeric complex with ALS2 oligomer which localize to the membrane compartments.

Anti-ALS2CL (N-terminal) antibody produced in rabbit is suitable for immunoblotting.

Anti-ALS2CL (N-terminal region) specifically recognizes human ALS2CL.

The co-expression of amyotrophic lateral sclerosis 2 (ALS2) C-terminal like (ALS2CL) along with Ras-related protein Rab-5A (Rab5) results in the distinctive tubulation phenotype of endosome compartments. It is responsible for the co-localization of ALS2CL and Rab5. ALS2CL protein has weak Rab5-guanine nucleotide exchange factor (GEF) activity, but predominantly adheres to Rab5. Also, it inhibits the ALS2 mediated endosome enlargement. ALS2CL might be considered as a critical moiety over ALS2, in modulating the ALS2 and Rab5 mediated endosome dynamics in the cell. The N-terminal region of the ALS2CL protein specifically controls endolysosomal trafficking induced by endosome-autophagosome. It is involved in the regulation of neurite growth.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Store at −20 °C. For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.