生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~125 kDa
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~1.5 mg/mL
技术
western blot: 1.5-3.0 μg/mL using SH-SY5Y cell lysates.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ALS2CL(259173)
一般描述
The amyotrophic lateral sclerosis 2 (ALS2) C-terminal like (ALS2CL) gene is an ALS2 homologous gene, mapped to human chromosome 3p21.31. The encoded protein is homo-dimeric and forms an heteromeric complex with ALS2 oligomer which localize to the membrane compartments.
应用
Anti-ALS2CL (N-terminal) antibody produced in rabbit is suitable for immunoblotting.
生化/生理作用
Anti-ALS2CL (N-terminal region) specifically recognizes human ALS2CL.
The co-expression of amyotrophic lateral sclerosis 2 (ALS2) C-terminal like (ALS2CL) along with Ras-related protein Rab-5A (Rab5) results in the distinctive tubulation phenotype of endosome compartments. It is responsible for the co-localization of ALS2CL and Rab5. ALS2CL protein has weak Rab5-guanine nucleotide exchange factor (GEF) activity, but predominantly adheres to Rab5. Also, it inhibits the ALS2 mediated endosome enlargement. ALS2CL might be considered as a critical moiety over ALS2, in modulating the ALS2 and Rab5 mediated endosome dynamics in the cell. The N-terminal region of the ALS2CL protein specifically controls endolysosomal trafficking induced by endosome-autophagosome. It is involved in the regulation of neurite growth.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
制备说明
Store at −20 °C. For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Kyoko Suzuki-Utsunomiya et al.
Biochemical and biophysical research communications, 354(2), 491-497 (2007-01-24)
ALS2, the causative gene product for a number of recessive motor neuron diseases, is a guanine-nucleotide exchange factor for Rab5, and acts as a modulator for endosome dynamics. Recently, we have identified a novel ALS2 homolog, ALS2CL, which is highly
Anatoly Uzdensky et al.
Molecular neurobiology, 54(6), 4172-4188 (2016-06-22)
After ischemic stroke, cell damage propagates from infarct core to surrounding tissues (penumbra). To reveal proteins involved in neurodegeneration and neuroprotection in penumbra, we studied protein expression changes in 2-mm ring around the core of photothrombotic infarct induced in the
Shinji Hadano et al.
FEBS letters, 575(1-3), 64-70 (2004-09-25)
ALS2, the causative gene product for juvenile recessive amyotrophic lateral sclerosis (ALS2), is a guanine-nucleotide exchange factor for the small GTPase Rab5. Here, we report a novel ALS2 homologous gene, ALS2 C-terminal like (ALS2CL), which encodes a 108-kD ALS2CL protein.
Ming He et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(5), 902-914 (2019-03-29)
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