conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
3H12, monoclonal
form
buffered aqueous solution
mol wt
~11 kDa
species reactivity
mouse, rat, human
concentration
~1.0 mg/mL
technique(s)
immunocytochemistry: suitable, western blot: 2-4 μg/mL using HeLa cell nuclear extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SUMO3(6612)
mouse ... Sumo3(20610)
rat ... Sumo3(499417)
General description
Monoclonal Anti-Sumo-2/3 (rat IgG2a isotype) is derived from the hybridoma 3H12 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a human SUMO3 fusion protein.
Small ubiquitin-like modifier 3 (SUMO3) is encoded by the gene mapped to human chromosome 21q22.3. The protein belongs to the ubiquitin-like protein family and is expressed mainly in cytoplasm.
Immunogen
human SUMO3 fusion protein
Application
Monoclonal Anti-Sumo-2/3 has been used in immunoblotting and immunocytochemistry.
Biochem/physiol Actions
Small ubiquitin-like modifier (SUMO) was identified as a post-translational protein modifier.
Small ubiquitin-like modifier 3 (SUMO3) plays a vital role in enhancing cellular responses to environmental stress. It acts as a key element of the leukemogenic network in transient myeloproliferative disorder (TMD) of the newborn/acute megakaryoblastic leukaemia (AMKL).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
相关内容
Instructions
SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis.
Castoralova M
Biochimica et Biophysica Acta, 1823, 911-919 (2012)
Molecular features of human ubiquitin-like SUMO genes and their encoded proteins
Su HL and Li SS
Gene, 296, 65-73 (2002)
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.
Saitoh H and Hinchey J.
The Journal of Biological Chemistry, 275, 6252-6258 (2000)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200190-200UL | 04061837898006 |
| SAB4200190-25UL | 04061837898013 |