SAB4200191
抗-Septin 9抗体，大鼠单克隆
clone Clone 1A6C2, purified from hybridoma cell culture
别名:
单克隆抗-Septin 9 大鼠抗, 抗-MLL, 抗-MSF, 抗-MSF1, 抗-NAPB, 抗-PNUTL4, 抗-SEPT9, 抗-SINT1, 抗-SeptD1, 抗-花生类4
产品名称
抗-Septin 9抗体，大鼠单克隆, clone Clone 1A6C2, purified from hybridoma cell culture
biological source
rat
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
Clone 1A6C2, monoclonal
form
buffered aqueous solution
mol wt
~72 kDa
species reactivity
human, rat, monkey, mouse
concentration
~1.0 mg/mL
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: 2.5-5.0 μg/mL using L929, HeLa, 3T3 and COS-7 cell extracts
isotype
IgG2a
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SEPT9(10801)
mouse ... Sept9(53860)
rat ... Sept9(83788)
Application
单克隆抗Septin 9可用于：
- 免疫印迹
- 免疫细胞化学
- 免疫组织化学
- 免疫荧光
Biochem/physiol Actions
Septin 9（SEPT9）与肿瘤发生有关。该基因的突变会导致遗传性神经痛性肌萎缩，也称为具有上臂神经炎。此外，SEPT9被证明是一种基于DNA甲基化的生物标志物，可以有效地将大肠癌与正常标本区分开。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
单克隆抗Septin 9（大鼠IgG2a同种型）来自杂交瘤1A6C2，该杂交瘤是通过小鼠骨髓瘤细胞和大鼠脾细胞融合而，大鼠脾细胞用与KLH偶联的大鼠Septin 9的N端相对应的合成肽免疫。Septin 9（SEPT9）是Septin家族（也称为MSF/eseptin/Sint1）的成员。该基因定位于人染色体17q25。
Immunogen
合成肽其对应于大鼠Septin 9的N末端序列，与KLH偶联
Physical form
溶于含有15 mM叠氮化钠的0.1M磷酸盐缓冲液（pH 7.4）。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Polarity of neuronal membrane traffic requires sorting of kinesin motor cargo during entry into dendrites by a microtubule-associated septin
Karasmanis EP, et al.
Developmental Cell, 46(2), 204-218 (2018)
Taro Tachibana et al.
Hybridoma (2005), 29(2), 169-171 (2010-05-07)
The septin family of GTPase proteins has been shown to be important for cell division, cytoskeletal organization, and membrane-remodeling events. Septin 9 (SEPT9) is a member of the septin family (also designated MSF/eseptin/Sint1) and has been implicated in tumorigenesis. The
Detection of methylated SEPT9 in plasma is a reliable screening method for both left-and right-sided colon cancers
Toth K, et al.
PLoS ONE, 7(9), e46000-e46000 (2012)
Mutations in SEPT9 cause hereditary neuralgic amyotrophy
Kuhlenbaumer G, et al.
Nature Genetics, 37(10), 1044-1044 (2005)
AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia
Gulten T, et al.
Journal of Clinical Laboratory Analysis, 23(6), 368-371 (2009)
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