SAB4200228
Anti-Glycogen Synthase 2 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-GYS2, Anti-Glycogen synthase 2 (liver), Anti-LGS
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Species reactivity:
rat, mouse
Application:
IHC, WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
form
buffered aqueous solution
mol wt
antigen ~85 kDa
species reactivity
rat, mouse
concentration
~1.0 mg/mL
technique(s)
immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded rat liver, western blot: 1.5-3 μg/mL using mouse liver extracts (S1 fraction)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Gys2(232493)
General description
Glycogen synthase 2 (GYS2) codes for a rate-limiting enzyme, glycogen synthase. The encoded protein is exclusively expressed in liver.
Immunogen
synthetic peptide located at the C-terminus of mouse glycogen synthase 2 (GYS2), conjugated to KLH. The corresponding sequence is highly conserved in rat GYS2 (single amino acid substitution) and in human GYS2 (84% identity).
Application
Anti-Glycogen Synthase 2 antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.
Biochem/physiol Actions
Glycogen synthase 2 (GS-2) plays a vital role as a rate limiting enzyme in glycogenesis pathway in liver and adipose tissue. It acts a target gene of peroxisome proliferator-activated receptors (PPARα, PPARβ/δ and PPARγ), which are transcription factors implicated in regulation of lipid and glucose metabolism. Mutation in the gene is associated with the pathogenesis of inherited monogenic disease glycogen storage disease 0 (GSD0).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice.
Irimia JM
The Journal of Biological Chemistry, 285, 12851-12861 (2010)
Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors
Mandard S
Cellular and Molecular Life Sciences, 64, 1145-1157 (2007)
相关内容
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