SAB4200230
Anti-DPP4/CD26 antibody, Mouse monoclonal
clone A6H, purified from hybridoma cell culture
别名:
Monoclonal Anti-ADABP, Monoclonal Anti-ADCP2, Monoclonal Anti-DPPIV, Monoclonal Anti-TP103, Monoclonal Anti-dipeptidyl-peptidase 4
产品名称
Anti-DPP4/CD26 antibody, Mouse monoclonal, clone A6H, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
A6H, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~4.0 mg/mL
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
indirect immunofluorescence: 20-40 μg/mL using methanol/acetone fixed HT-29 cells
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DPP4(1803)
Application
Monoclonal Anti-DPP4/CD26 antibody produced in mouse has been used in:
- enzyme linked immuno sorbent assay (ELISA)
- immunocytochemistry
- immunohistochemistry
- flow cytometry
Biochem/physiol Actions
Dipeptidyl peptidase-4 (DPP4) is involved in the regulation of the biological activity of hormones and chemokines, such as glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. DPP4 inhibition maybe used to treat type 2 diabetes mellitus. It acts as a T cell activation molecule and regulates immunity and immune-mediated disorders.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-DPP4/CD26 (mouse IgG1 isotype) is derived from the hybridoma A6H produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human fetal homogenates. Dipeptidyl peptidase-4 (DPP4) belongs to the S9B protein family, which cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides and peptide hormones. It is a type II transmembrane glycoprotein, expressed on the surface of many cell types.
Immunogen
human fetal homogenates.
Physical form
Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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flash_point_c
Not applicable
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
法规信息
新产品
此项目有
R L Vessella et al.
Cancer research, 45(12 Pt 1), 6131-6139 (1985-12-01)
Monoclonal antibodies (MABs) reactive with human renal cell carcinoma (RCC) were generated following immunization of mice with either RCC homogenates, RCC cell lines, or fetal kidney homogenates. The characteristics of four highly reactive immunoglobulin G1 MABs, designated UMVA-RCC-A6H, UMVA-RCC-A36, UMVA-RCC-C5H
Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme
Matteucci E and Giampietro O
Current Medicinal Chemistry, 16(23), 2943-2951 (2009)
Vlad Tocan et al.
The Journal of biological chemistry, 297(6), 101354-101354 (2021-11-01)
Hepatocytes differ from columnar epithelial cells by their multipolar organization, which follows the initial formation of central lumen-sharing clusters of polarized cells as observed during liver development and regeneration. The molecular mechanism for hepatocyte polarity establishment, however, has been comparatively
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