SAB4200283
Anti-Tensin 1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-TNS1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC, WB
Citations:
12
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 225 kDa (rat), antigen ~150 kDa (human)
species reactivity
rat, human, chicken
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded rat heart., indirect immunofluorescence: 3-6 μg/mL using chicken embryo fibroblast cells., western blot: 1-2 μg/mL using lysates of HEK-293T cells overexpressing human tensin 1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TNS1(7145)
mouse ... Tns1(21961)
rat ... Tns1(301509)
General description
Tensin 1 (TNS1) is encoded by the gene mapped to human chromosome 2q35. The encoded protein is localized to focal adhesions and is mainly expressed in renal tubular epithelial cells (TECs).
Immunogen
synthetic peptide corresponding to a sequence located in the internal region of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.
Application
Anti-Tensin 1 antibody may be used in immunofluorescence and immunohistochemistry.
Anti-Tensin 1 antibody produced in rabbit has been used in immunostaining and immunoblotting.
Biochem/physiol Actions
Tensin 1 (TNS1) contributes to transforming growth factor (TGF)-β-induced myofibroblast differentiation and extracellular fibronectin and collagen matrix formation. Disruption in the gene and associated signaling might hinder tissue fibrosis. The encoded protein anchors to stress fibers by interacting with cytoplasmic tails of integrins and increases metastatic abilities of cancer cells. Tensin plays a vital role in activation of the c-Jun N-terminal kinases (JNK) and p38 pathways.
Tensin 1 associates with actin, integrin, FAK, p130Cas, DLC-1 and protein phosphatase PP1 which affects cell polarization, migration and invasion. Tensin 1 undergoes extensive Ser/Thr and Tyr phosphorylation induced by extracellular matrix (ECM), various growth factors and oncogenes. In addition, tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Tensin is potentially involved in extracellular matrix production in mesangial cells.
Yamashita M
Histochemistry and Cell Biology, 121, 245-254 (2004)
Genetic association analyses highlight biological pathways underlying mitral valve prolapse
Dina C
Nature Genetics, 47, 1206?1211-1206?1211 (2015)
Tensin can induce JNK and p38 activation.
Katz BZ
Biochemical and Biophysical Research Communications, 272, 717-720 (2000)
Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation.
Bernau K
American Journal of Respiratory Cell and Molecular Biology, 56, 465-476 (2017)
Tensin
Lo S H
The International Journal of Biochemistry & Cell Biology, 36(1), 31-34 (2004)
相关内容
Instructions
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