Anti-acetyl-Histone H3 [Ac-Lys⁵⁶]

Histones are considered as the important constituents of chromatin. They are classified into core histones and linker histones. Histone H3 gene codes for a H3 protein sequence. This H3 gene is located on human chromosome 1 (1q42).

synthetic peptide containing acetylated Lys⁵⁶ of human histone H3, conjugated to KLH. The corresponding sequence is identical in many species including rat and mouse histone H3.

Anti-acetyl-Histone H3 [Ac-Lys56] has been used in western blot analysis.

Core histones and linker histones are known possesses inter and intra-specific amino acid sequence variability. Histone modifications are thought to play an important role in cancer and disease. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. In human embryonic stem cells, histone H3 Lys56 acetylation is associated to the core transcriptional network.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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