SAB4200420
Anti-Lamin A, mature antibody, Mouse monoclonal
clone 4A4, purified from hybridoma cell culture
别名:
Anti-LMN1, Anti-LMNA, Anti-Lamin A/C, Anti-Prelamin-A/C, Monoclonal Anti-Lamin A, mature antibody produced in mouse
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
4A4, monoclonal
Application:
IF, WB
Citations:
7
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
4A4, monoclonal
form
buffered aqueous solution
mol wt
antigen ~72 kDa
species reactivity
human
enhanced validation
independent
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 0.25-0.5 μg/mL using human HeLa cells, western blot: 0.25-0.5 μg/mL using whole extracts of human HeLa cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LMNA(4000)
General description
Lamin A is encoded by the gene with exons 1–12, mapped on human chromosome 1q21-22. The encoded protein is a major component of the inner nuclear membrane lamina. Lamin A is expressed in variety of tissues, including adult heart and skeletal muscle.
Immunogen
synthetic peptide corresponding to the C-terminus of mature human Lamin A.
Application
Monoclonal Anti-Lamin A, mature antibody produced in mouse has been used in immunohistochemistry.
Biochem/physiol Actions
Lamin A can be used as a biomarker for cancer diagnosis and prognosis. It also plays a major role in maintaining cardiac homeostasis. Mutation in the gene is associated with Emery-Dreifuss muscular dystrophy (EDMD-AD) and Hutchinson–Gilford progeria syndrome (HGPS). In addition, variation in the gene expression also leads to various disorders such as, lipodystrophy, progeria, muscular dystrophy, neuropathy and cardiomyopathy.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Juvenile-onset generalized lipodystrophy due to a novel heterozygous missense LMNA mutation affecting lamin C.
Patni N
American Journal of Medical Genetics. Part A, 173, 2517-2521 (2017)
Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease.
Mastroeni D
Neurobiology of Aging, 36, 3121-3129 (2015)
Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.
Kaspi E
PLoS ONE, 12 (2017)
Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease
Fatkin D
The New England Journal of Medicine, 341, 1715-1724 (1999)
Increased ventilatory response to exercise in symptomatic and asymptomatic LMNA mutation carriers: a follow-up study.
Ollila L
Clinical Physiology and Functional Imaging, 37, 8-16 (2017)
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