SAB4200450
Anti-SOX11 (C-terminal) antibody produced in rabbit
IgG fraction of antiserum
别名:
Anti-SRY (sex determining region Y)-box 11
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human
technique(s)
immunohistochemistry: 1:100-1:200 using formalin-fixed paraffin-embedded rat brain and cerebellum., indirect immunofluorescence: 1:100-1:200 using human HeLa cells., western blot: 1:4000-1:8000 using whole extracts of HEK-293T cells overexpressing human recombinant SOX11
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SOX11(6664)
General description
Sex determining region Y (SRY)-box 11 (SOX11) protein belongs to the SRY-related high mobility group (HMG)-box (SOX) family of transcription factors. This protein is localized in adult immature neurons but is normally not expressed in any other adult tissue. SOX11 gene is located on the human chromosome 2p25.2.
Immunogen
peptide corresponding to the C-terminal region of human SOX11, conjugated to KLH. The corresponding sequence is identical in monkey, bovine and pig and differs by a single amino acid in mouse and rat.
Application
Anti-SOX11 (C-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Biochem/physiol Actions
Anti-SOX11 (C-terminal) recognizes human and rat SOX11.
Sex determining region Y (SRY)-box 11 (SOX11) plays a role in the regulation of tissue remodeling during embryogenesis which is essential for neurogenesis. This protein is also involved in tumorigenesis. SOX11 protein also plays a role in the determination of cell fate. Upregulation of the SOX11 gene leads to ovarian cancer, brain tumor, medulloblastomas and gliomas. This protein functions as a biomarker in mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL) and Burkitt lymphomas (BL).
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Esther Palomino Lago et al.
Animals : an open access journal from MDPI, 14(1) (2024-01-11)
Fractures caused by bone overloading are a leading cause of euthanasia in Thoroughbred racehorses. The risk of fatal fracture has been shown to be influenced by both environmental and genetic factors but, to date, no specific genetic mechanisms underpinning fractures
Maria Carmela Vegliante et al.
PloS one, 6(6), e21382-e21382 (2011-07-09)
Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem cells, normal hematopoietic cells
Xiao Wang et al.
PloS one, 5(11), e14085-e14085 (2010-12-03)
The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet
Lakshmi Pillai-Kastoori et al.
PLoS genetics, 10(7), e1004491-e1004491 (2014-07-11)
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog signaling is known to play a critical
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