SAB4200528
Anti-HMGCR antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-3-hydroxy-3-methylglutaryl-CoA reductase, LDLCQ3
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect immunofluorescence
western blot
western blot
Species reactivity:
human
Citations:
8
Technique(s):
indirect immunofluorescence: 1.0-2.0 μg/mL using mevastatin-treated HepG2 cells.
western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells.
western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells.
Uniprot accession no.:
产品名称
Anti-HMGCR antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 100 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 1.0-2.0 μg/mL using mevastatin-treated HepG2 cells.
western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HMGCR(3156)
Immunogen
synthetic peptide corresponding to an internal sequence of human HMGCR, conjugated to KLH. The corresponding sequence is identical in human HMGCR isoform 2 and has 87% sequence identity in mouse HMGCR and 81% identity in rat HMGCR.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Application
Anti-HMGCR antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a major role in mevalonate biosynthesis, which is a rate limiting step of cholesterol biosynthesis in the liver. Additionally, it also plays a key role in various biological process such as, embryogenesis and cancer. Elevated expression of the gene is associated with the development of gastric cancer(GC) and glioblastoma cells. Thus, HMGCR can be considered as a potent therapeutic target for GC and glioblastoma. Polymorphism in HMGCR results in late-onset Alzheimer′s disease.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) codes for a part of the statin-binding domain of the enzyme. This gene is located on human chromosome 5q13. HMGCR has a molecular mass of 97 kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese.
Chang XL, et al.
Oncotarget, 7(16), 22746?22751-22746?22751 (2016)
Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila.
Belgacem YH and Martin JR
PLoS ONE, 2(1), e187-e187 (2007)
Jittima Tomacha et al.
Frontiers in pharmacology, 12, 696961-696961 (2021-08-24)
An aberrant regulation of lipid metabolism is involved in the pathogenesis and progression of cancer. Up-regulation of lipid biosynthesis enzymes, including acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN) and HMG-CoA reductase (HMGCR), has been reported in many cancers. Therefore, elucidating
Yuval Yogev et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(7), e2217831120-e2217831120 (2023-02-07)
Myopathy is the main adverse effect of the widely prescribed statin drug class. Statins exert their beneficial effect by inhibiting HMG CoA-reductase, the rate-controlling enzyme of the mevalonate pathway. The mechanism of statin myopathy is yet to be resolved, and
Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila
Belgacem YH and Martin JR
PLoS ONE, 2 (2007)
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