产品名称
抗 心肌素 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~107 kDa
species reactivity
rat, human, mouse
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry: 5-10 μg/mL using human and chicken heart.
indirect immunofluorescence: 2-4 μg/mL using A10 cells.
western blot: 1.5-3.0 μg/mL using extracts of Hct116 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYOCD(93649)
mouse ... Myocd(214384)
rat ... Myocd(246297)
Biochem/physiol Actions
Myocardin（MYOCD）可作为血清应答因子（SRF）的重要平滑肌和心肌特异性转录共激活因子。它在平滑肌细胞（SMC）分化中起着至关重要的作用。编码的蛋白调节骨形态发生蛋白10（BMP10）表达，是心脏发育、心肌细胞存活和心脏功能维护所必需的。MYOCD 表达与动脉粥样硬化、阿尔茨海默病的发展和恶性转化有关。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或人类或动物应用。
General description
抗Myocardin 特异性地识别人、大鼠和鸡 myocardin （(MYOCD).）。Myocardin由定位至人类染色体17p11.2上的基因所编码。它包含保守的SAP（SAF-A/B、Acinus和 PIAS）结构域，参与调节核组织结构、染色体动力学和细胞凋亡。编码的蛋白以精确发育调节、谱系限制性模式在胚胎以及出生后发育过程中表达。
Immunogen
一种相应的 KLH 偶联的人心肌素内部序列对应的合成肽。相应的的序列在人心肌素亚型 2 和大鼠及小鼠中相同。
Physical form
溶于含 15 mM 叠氮化钠的 0.01 M 磷酸盐缓冲盐水 (pH 7.4) 中。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Loss of heterozygosity: what is it good for?
Ryland GL, et al.
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Myocardin in Tumor Suppression and
Myofibroblast Differentiation
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Shats I, et al.
Cell Cycle, 6, 1141-1146 (2007)
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Physiological reports, 10(18), e15410-e15410 (2022-09-20)
In vivo angiotensin II (AngII)-treatment is a widely used experimental model to induce cardiovascular disease and results in a high likelihood of abdominal aorta aneurysm (AAA) formation. This involves progressive and irreversible focal dilation of the abdominal aorta and induces
Myocardin regulates BMP10 expression and is required for heart development
Huang J, et al.
The Journal of Clinical Investigation, 122, 3678-3691 (2012)
Sofie De Moudt et al.
Communications biology, 5(1), 605-605 (2022-06-18)
Aortic stiffness is a hallmark of cardiovascular disease, but its pathophysiology remains incompletely understood. This study presents an in-dept characterization of aortic aging in male C57Bl/6 mice (2-24 months). Cardiovascular measurements include echocardiography, blood pressure measurement, and ex vivo organ
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