SAB4200566
Anti-KHSRP antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-FBP2, Anti-FUBP2, Anti-KH-type splicing regulatory protein, Anti-KSRP, Anti-MGC99676
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
8
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~82 kDa
species reactivity
rat, mouse, human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 1-2 μg using lysates of human HEK-293T cells, western blot: 0.25-0.50 μg/mL using whole extracts of mouse NIH-3T3 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KHSRP(8570)
mouse ... Khsrp(16549)
rat ... Khsrp(171137)
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General description
K-homology type-splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein. It contains four K homology RNA-binding domains and an unusual C-terminal domain. KHSRP is localized in neural and non-neural cell lines. It is located on the human chromosome at 19p13.3.
Immunogen
synthetic peptide corresponding to an internal region of human KHSRP (GeneID: 8570), conjugated to KLH. The corresponding sequence is identical in rat, mouse, monkey, pig and dog KHSPR.
Application
Anti-KHSRP antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Anti-KHSRP recognizes human, mouse and rat KHSRP.
K-homology type-splicing regulatory protein (KHSRP) is involved in several cellular processes such as transcription, mRNA localization and alternative pre-mRNA splicing. It is also involved in mRNA decay and microRNA precursor maturation.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease
Briata P, et al.
Wiley Interdisciplinary Reviews. RNA, 7(2), 227-240 (2016)
A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.
Min H, et al.
Genes & Development, 11(8), 1023-1036 (1997)
Mapping of theKHSRPGene to a Region of Conserved Synteny on Human Chromosome 19p13. 3 and Mouse Chromosome 17
Ring H Z, et al.
Genomics, 56(3), 350-352 (1999)
A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3'UTR-Mediated Protein-Protein Interactions
Ma W and Mayr C
Cell, 175(6), 1492-1506 (2018)
Gain of Additional BIRC3 Protein Functions through xn-3-t6a-UTR-Mediated Protein Complex Formation
Lee SH and Mayr C
Molecular Cell, 74(4), 701-712 (2019)
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