SAB4200574
Anti-Claudin-4 (C-terminal) antibody produced in rabbit
affinity isolated antibody
别名:
(CPER), CLDN4, CPE-R, CPETR1, Clostridium, Williams-Beuren syndrome chromosomal region 8(WBSCR8), enterotoxin, hCPE-R, perfringens, receptor
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, human, canine
technique(s)
immunoblotting: suitable, immunofluorescence: suitable, immunohistochemistry: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CLDN4(1364)
General description
Claudin-4 is heterogeneously expressed in various tissues. It is enriched in endothelial cells (ECs), including the blood-brain barrier, and is also expressed in gut and kidney. It is mapped to human chromosome 7q11.23. Claudin-4 is associated with the tight junction strands in kidney epithelial cells.
Application
Anti-Claudin-4 (C-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Biochem/physiol Actions
Anti-Claudin-4 (C-terminal) specifically recognizes human, rat and dog claudin-4.
Claudin-4 is involved in maintaining cellular polarity. It favors sodium chloride absorption and acts as a cation-barrier. Claudin-4 expression has been shown to be deregulated in several cancers, with aberrant expression in ovarian, breast, prostate and pancreatic carcinomas. The gene location of claudin-4 is a Williams-Beuren syndrome critical region.
Physical form
Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Williams-Beuren syndrome: a challenge for genotype-phenotype correlations
Tassabehji, M
Human Molecular Genetics, 12, R229-R237 (2003)
Clinical utility gene card for: Williams-Beuren Syndrome [7q11. 23]
Koehler U, et al.
European Journal of Human Genetics, 22(9), 1153-1153 (2014)
Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity
Agarwal R, et al.
Cancer Research, 65(16), 7378-7385 (2005)
Claudin-1,-2,-4, and-5: comparison of expression levels and distribution in equine tissues
Lee B, et al.
Journal of Veterinary Science, 17(4), 445-451 (2016)
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