SAB4200585
Anti-ERGIC-53 antibody, Mouse monoclonal
clone ERGIC-3, purified from hybridoma cell culture
别名:
Monoclonal Anti-ER-Golgi intermediate compartment 53 kDa protein, Monoclonal Anti-ERGIC-53 antibody produced in mouse, Monoclonal Anti-ERGIC53, Monoclonal Anti-F5F8D, Monoclonal Anti-Gp58, Monoclonal Anti-Intracellular mannose-specific lectin MR60, Monoclonal Anti-LMAN1, Monoclonal Anti-Lectin mannose-binding 1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
ERGIC-3, monoclonal
Application:
—
Citations:
6
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
ERGIC-3, monoclonal
form
buffered aqueous solution
mol wt
antigen ~58 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
immunoblotting: 1-2 μg/mL using whole extracts of human HeLa cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LMAN1(3998)
mouse ... Lman1(70361)
rat ... Lman1(116666)
General description
Endoplasmic reticulum-Golgi intermediate compartment 53kDa protein (ERGIC-53), a nonglycosylated, hexameric type I integral membrane protein is also known as LMAN1 (lectin, mannose-binding 1). This gene is located on human chromosome 18q21.32.
Immunogen
synthetic peptide corresponding to an internal sequence of human ERGIC-53, conjugated to KLH. The corresponding sequence is identical in mouse, rat, bovine and monkey.
Biochem/physiol Actions
Endoplasmic reticulum-Golgi intermediate compartment protein 53kDa protein (ERGIC-53) plays an important role in the proliferation of arenavirus, coronavirus and filovirus. This intracellular cargo receptor enables the anterograde passage of very few glycoprotein ligands in the early exocytic pathway. Mutations in ERGIC-53 (LMAN1) gene results in the deficiency of factor V and factor VIII.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Two new mutations at ERGIC-53 gene in a Turkish family
Torun, et al.
Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(3), 248-250 (2011)
Dependence on electron transport chain function and intracellular signaling of genomic responses in SH-SY5Y cells to the mitochondrial neurotoxin MPP+
Brill L B II, et al.
Experimental Neurology, 181(1), 25-38 (2003)
Morihisa Fujita et al.
The Journal of cell biology, 194(1), 61-75 (2011-07-06)
Glycosylphosphatidylinositol (GPI) anchoring of proteins is a posttranslational modification occurring in the endoplasmic reticulum (ER). After GPI attachment, proteins are transported by coat protein complex II (COPII)-coated vesicles from the ER. Because GPI-anchored proteins (GPI-APs) are localized in the lumen
The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles
Klaus JP, et al.
Cell host & microbe, 14(5), 522-534 (2013)
Mariana L Ferrari et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(27), 13582-13591 (2019-06-19)
Intracellular trafficking pathways in eukaryotic cells are essential to maintain organelle identity and structure, and to regulate cell communication with its environment. Shigella flexneri invades and subverts the human colonic epithelium by the injection of virulence factors through a type
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