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Merck
CN

SAB4200631

Monoclonal Anti-CYBA antibody produced in mouse

clone CB-64, purified from hybridoma cell culture

别名:

Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, cytochrome b-245 alpha polypeptide, p22-PHOX

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

Monoclonal Anti-CYBA antibody produced in mouse, clone CB-64, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CB-64, monoclonal

form

buffered aqueous solution

species reactivity

bovine, mouse, rat, monkey, human, canine

concentration

~1 mg/mL

technique(s)

flow cytometry: 5-10 μg/test using HeLa cells.
immunoblotting: 0.5-1 μg/mL using whole extracts of HeLa cells.
immunofluorescence: 5-10 μg/mL using HeLa cells.

isotype

IgM

UniProt accession no.

P13498

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified, unmodified

Quality Level

200

Gene Information

human ... CYBA(1535)
mouse ... Cyba(13057)
rat ... Cyba(79129)

相关类别

Application

Monoclonal Anti-CYBA antibody produced in mouse has been used in:
  • immunoblotting
  • flow cytometry
  • immunofluorescence

Biochem/physiol Actions

In prostate cancer cells downregulation of cytochrome b245, alpha polypeptide/light chain (CYBA) was reported to inhibited cell proliferation and colony formation, through AKT and ERK1/2 signaling pathways, indicating CYBA has a role in tumor angiogenesis and tumor growth. Mutations in this gene causes an autosomal recessive forms of chronic granulomatous disease (AR220CGD).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-CYBA (mouse IgM isotype) is derived from the hybridoma CB-64 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the internal region of human CYBA, conjugated to keyhole limpet hemocyanin (KLH). The small subunit, p22phox subunit, also known as cytochrome b245, alpha polypeptide/light chain (CYBA) is membrane bound,which is expressed in phagocytic, endothelial and vascular smooth muscle cells. This gene is located on human chromosome16q24

Immunogen

Synthetic peptide corresponding to a sequence at the internal region of human CYBA .

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
065M4807V
065M4807V

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CYBA encoding p22phox, the cytochrome b558 alpha polypeptide: gene structure, expression, role and physiopathology
Stasia MJ
Gene, 586(1) (2016)
Three novel mutations in CYBA among 22 Iranians with Chronic granulomatous disease
Badalzadeh M, et al.
International Journal of Immunogenetics, 44(6) (2017)
NADPH oxidase subunit p22phox-mediated reactive oxygen species contribute to angiogenesis and tumor growth through AKT and ERK1/2 signaling pathways in prostate cancer
Li Q, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1833(12) (2013)
Is the C242T Polymorphism of the CYBA Gene Linked with Oxidative Stress-Associated Complications of Prematurity
Huizing MJ, et al.
Antioxidants & Redox Signaling, 27(17) (2017)

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