产品名称
Monoclonal Anti-C10orf54 antibody produced in mouse, clone ORF.4, purified from hybridoma cell culture
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
ORF.4, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
flow cytometry: 10 μg/test using human platelets
immunohistochemistry: suitable
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... C10orf54(64115)
Application
Phosphotyrosine antibody inhibitor has been used in flow-cytometry and immunohistochemistry.
Biochem/physiol Actions
Studies suggest that C10orf54 (Chromosome 10 open reading frame 54) functions as a co-inhibitory ligand and restricts the mechanism of T cell proliferation and cytokine production. It was also suggested that C10orf 54 acts as a positive regulator as well as a substrate of MT1-MMP (trans-membrane type 1-matrix metalloproteinase) during tumor growth of collagen matrix, which regulates invasive growth.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-C10orf54 (mouse IgG1 isotype) is derived from the hybridoma OR.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide.C10orf54 (Chromosome 10 open reading frame 54) is also referred to as GI24, B7 member B7-H5, VISTA (V-domain Ig suppressor of T cell activation) and Dies1. It is a novel surface glycoprotein belonging to the B7 immunoglobulin superfamily. It consists of a single IgV domain with 3 additional cysteine residues and a cytoplasmic tail. It is expressed on mature myeloid APCs (antigen-presenting cells) including peritoneal macrophages, mature BMDC (bone marrow-derived dendritic cell), neutrophils and CD11c+ DCs, and to a lesser quantity in T cells and activated Treg cells.
Immunogen
synthetic peptide corresponding to a sequence at the internal region of human C10orf54
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Keunok Jung et al.
Immune network, 13(5), 184-193 (2013-11-08)
Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T
Li Wang et al.
The Journal of experimental medicine, 208(3), 577-592 (2011-03-09)
The immunoglobulin (Ig) superfamily consists of many critical immune regulators, including the B7 family ligands and receptors. In this study, we identify a novel and structurally distinct Ig superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family
Moustafa A Sakr et al.
Cancer science, 101(11), 2368-2374 (2010-07-30)
GI24, an immunoglobulin superfamily member, has been cloned from a placenta cDNA library as a gene product that promoted activation of matrix metalloproteinase (MMP)-2 mediated by membrane type (MT) 1-MMP. Co-expression of GI24 with MT1-MMP in HEK293T cells increased the
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