SAB4200672
Monoclonal Anti-CDH13 antibody produced in mouse
clone CAD-5, purified from hybridoma cell culture
别名:
Anti-CDHH, Anti-Cadherin 13, Anti-P105
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
CAD-5, monoclonal
Application:
IHC, IP
Citations:
2
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CAD-5, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunoblotting: 5-10 μg/mL using whole extract of human HeLa cells., immunohistochemistry: 5-10 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human heart sections, immunoprecipitation (IP): 5-10 μg/mL using whole extract of human HeLa cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CDH13(1012)
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General description
Monoclonal Anti-CDH13 (mouse IgG1 isotype) is derived from the hybridoma CAD-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Cadherin 13 (CDH13) is a member of the cadherins multigene family of single-chain glycoprotein receptors. It is a glycosylphosphatidylinositol (GPI)- anchored member and a low-density lipoprotein (LDL)-binding protein usually found in smooth muscle. CDH13 is present in the brain and cardiovascular system. It is mapped on the human chromosome at 16q23.3.
Immunogen
N-terminal His-tagged recombinant protein of human Cadherin 13
Application
Monoclonal Anti-CDH13 antibody produced in mouse may be used in:
- immunoblotting
- immunoprecipitation
- immunohistochemistry
Biochem/physiol Actions
Cadherin (CDH) is involved in mediating Ca2+-dependent cell-cell adhesion. Abnormalities in the CDH13 gene have been identified in human malignancies. Promoter methylation of CDH13 results in gene silencing in non-small cell lung carcinoma (NSCLC). CDH13 is involved in cell migration, axon guidance and neurite growth. It is also associated with attention-deficit/hyperactivity disorder (ADHD). CDH13 is also involved in autism spectrum disorders, bipolar disorder, schizophrenia and depression.
Monoclonal Anti-CDH13 recognizes human Cadherin 13.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
Preparation Note
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Legal Information
ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations
Org E, et al.
Human Molecular Genetics, 18(12), 2288-2296 (2009)
Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition
Rivero O, et al.
Translational Psychiatry, 5(10), e655-e655 (2015)
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