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Merck
CN

SAB4200685

Anti-Glucagon antibody, Mouse monoclonal

clone K79bB10, purified from hybridoma cell culture

别名:

Monoclonal Anti-Glucagon antibody produced in mouse, GCG, GLP1, GLP2, GRPP

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关于此项目

NACRES:
NA.41
UNSPSC Code:
51111800
Clone:
K79bB10, monoclonal
Species reactivity:
cat, rabbit, mouse, guinea pig, rat, dog, porcine, zebrafish, human
Application:
IHC, RIA
Citations:
8

主要文件

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biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

K79bB10, monoclonal

form

buffered aqueous solution

species reactivity

cat, rabbit, mouse, guinea pig, rat, dog, porcine, zebrafish, human

packaging

antibody small pack of 25 μL

concentration

~1 mg/mL

technique(s)

immunohistochemistry: 5-10 μg/mL using heat−retrieved formalin-fixed, paraffin-embedded Rat pancreas sections and Biotin/ExtrAvidin®-Peroxidase staining system., radioimmunoassay: suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

cat ... Gcg(101097825)
dog ... Gcg(403571)
guinea pig ... Gcg(100135526)
human ... GCG(2641)
mouse ... Gcg(14526)
pig ... Gcg(397595)
rabbit ... Gcg(100341777)
rat ... Gcg(24952)

General description

Glucagon is a hormone peptide produced in Langerhans islets α-cells in the pancreas. The active form of glucagon is derived from the cleavage of preproglucagon (GCG). Additional cleavage peptides are oxyntomodulin and glucagon-like peptide-1 (GLP1).

Immunogen

Polymerized porcine glucagon

Application

Monoclonal Anti-Glucagon antibody produced in mouse has been used in immunofluorescence staining. The product may be used in several immunochemical techniques including immunohistochemistry and radioimmunoassay (RIA).

Biochem/physiol Actions

The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis and ketogenesis. Glucagon has an antagonistic effect in the maintenance of normoglycemia to those of insulin and is suppressed by GLP1. Thus up-regulation of glucagon is leading to increased blood glucose levels. Glucagon-specific antibodies would prove useful as a Langerhans islets α cell, glucagonomas and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Legal Information

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

低风险生物材料
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000529766
0000483591
0000483591
0000529766
0000490146

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Pancreatic regulation of glucose homeostasis
Roder PV, et al.
Experimental & Molecular Medicine, 48(3), e219-e219 (2016)
Metabolic regulation of GLP-1 and PC1/3 in pancreatic
Sancho V, et al.
Testing, 12 (2017)
Qingsheng Liu et al.
Advanced materials (Deerfield Beach, Fla.), 33(39), e2102852-e2102852 (2021-08-08)
Encapsulation of insulin-producing cells is a promising strategy for treatment of type 1 diabetes. However, engineering an encapsulation device that is both safe (i.e., no cell escape and no breakage) and functional (i.e., low foreign-body response (FBR) and high mass
The role of glucagon on type 2 diabetes at a glance
Godoy-Matos AF, et al.
Diabetology & Metabolic Syndrome, 6 (2014)
Sara Ibrahim et al.
Disease models & mechanisms, 13(6) (2020-05-28)
Maladaptive signaling by pro-inflammatory cytokines (PICs), such as TNFα, IL1β and IFNɣ, can activate downstream signaling cascades that are implicated in the development and progression of multiple inflammatory diseases. Despite playing critical roles in pathogenesis, the availability of in vivo
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