SAB4200700
Anti-MR-Pro ADM antibody, Mouse monoclonal
clone MR2.1, purified from hybridoma cell culture
别名:
Midregional proadrenomedullin
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NACRES:
NA.41
UNSPSC Code:
51111800
Conjugate:
unconjugated
Clone:
MR2.1, monoclonal
Application:
IHC
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MR2.1, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunoblotting: 1-2 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92), immunohistochemistry: 2.5-5 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human Pancreas sections
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADM(133)
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General description
Anti-MR-Pro ADM antibody, Mouse monoclonal (MidRegional pro-Adrenomedullin) (mouse IgG2a isotype) is derived from the hybridoma MR2.1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH. The precursor peptide of Adrenomedullin (ADM), prepro-ADM, is processed to the circulating form of ADM. During this processing, other peptides are also being generated; PAMP (proadrenomedullin N-terminal 20 peptide) with suggested hypotensive effect, and MR-pro ADM (Mid-Regional pro-Adrenomedullin) which consists of 47 amino acid-propeptide.
Immunogen
Synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH.
Application
Anti-MR-Pro ADM antibody has been used in immunoblotting, immunohistochemistry.
Biochem/physiol Actions
MR-pro ADM (MidRegional pro-Adrenomedullin) has been suggested as a biomarker for plasma concentrations of Adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Increased levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. In dialysis patients MR-pro ADM and MR-pro ANP were shown to be associated with mortality in general and particularly with cardiovascular related mortality, with the highest risk when both parameters were elevated.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
Legal Information
ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
Christ-Crain M, et al.
Critical Care, 9(6), R816-R816 (2005)
Adrenomedullin, a multifunctional regulatory peptide.
Hinson JP, et al.
Endocrine Reviews, 21(2), 138-167 (2000)
Prognostic value of mid-regional pro-adrenomedullin in patients with heart failure after an acute myocardial infarction
Klip I T, et al.
Heart, 97(11), 892-898 (2011)
Ghazaleh Gouya et al.
PloS one, 6(3), e17803-e17803 (2011-03-17)
High levels of the plasma peptides mid-regional pro-adrenomedullin (MR-proADM) and mid-regional pro-atrial natriuretic peptide (MR-proANP) are associated with clinical outcomes in the general population. Data in patients with chronic kidney disease are sparse. We therefore investigated the association of MR-proANP
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