SAB4200706
Anti-TM4SF4 antibody, Mouse monoclonal
clone TM4SF-11, hybridoma cell culture supernatant
别名:
Anti-ILTMP, Anti-il-TMP transmembrane 4 L six family member 4
产品名称
Anti-TM4SF4 antibody, Mouse monoclonal, clone TM4SF-11, hybridoma cell culture supernatant
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
TM4SF-11, monoclonal
form
buffered aqueous solution
mol wt
antigen ~27 kDa
species reactivity
rat, human, canine, monkey, mouse, bovine
technique(s)
immunoblotting: 1:4,000-1:8,000 using whole extract of HCT-116 cells
isotype
IgM
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TM4SF4(7104)
mouse ... Tm4sf4(229302)
rat ... Tm4sf4(116467)
Application
Anti-TM4SF4 antibody has been used in immunoblotting.
Biochem/physiol Actions
TM4SF4 (Transmembrane 4 L6 Family member 4) can intervene density-dependent cell proliferation. TM4SF4 levels increases in non-dividing epithelial cells during their differentiation and migration of intestinal crypts. TM4SF4 levels are upregulated in 80% of hepatocellular carcinoma (HCC) tissues and in stomach adenocarcinoma cells. Reduction of TM4SF4 expression in HCC cell lines by stably transfecting TM4SF4 antisense plasmid caused significant inhibition of cell proliferation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-TM4SF4 antibody, Mouse monoclonal (mouse IgM isotype) is derived from the TM4SF-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide from the internal region of human TM4SF4, conjugated to KLH. TM4SF4 (Transmembrane 4 L6 Family member 4) also known as ILTMP (intestine and liver tetraspan membrane protein) is a member of the transmembrane 4 superfamily (or tetraspanin family). It is a cell surface glycoprotein containing four transmembrane domains.
Immunogen
synthetic peptide from the internal region of human TM4SF4
Physical form
The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth
Li Y, et al.
Acta biochimica et biophysica Sinica, 44(3), 224-232 (2012)
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