SAB4200744
Anti-BDNF antibody, Mouse Monoclonal
clone BDNF129-13, purified from hybridoma cell culture
别名:
Anti-Abrineurin, Anti-Brain-derived neurotrophic factor
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
BDNF129-13, monoclonal
Application:
ICC, IHC, IP
Citations:
5
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
BDNF129-13, monoclonal
form
buffered aqueous solution
mol wt
~12 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoblotting: 2-4 μg/mL using lysate of human HEK-293T cells over-expressing human BDNF protein, immunocytochemistry: suitable, immunohistochemistry: 20-40 μg/mL using pronase retrieved formalin-fixed, paraffin-embedded human cerebellum sections, immunoprecipitation (IP): 10-20 μg/mL using lysate of human HEK-293T cells over-expressing human BDNF protein
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BDNF(627)
General description
Anti-BDNF antibody, Mouse monoclonal, (mouse IgG2b isotype) is derived from the BDNF129-13 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/C mouse. Brain-derived neurotrophic factor (BDNF), also known as Abrineurin, is a secreted dimeric protein, which belongs to the neurotrophin family of growth factors, along with nerve growth factor (NGF) and neurotrophins 3, 4/5 and 6. BDNF is widely expressed in the central nerve system (CNS).
Immunogen
Synthetic peptide corresponding to a region located in the mature human BDNF protein conjugated to KLH
Application
Anti-BDNF antibody, Mouse Monoclonal has been used in:
- immunoblotting
- immunohistochemistry
- immunoprecipitation
- immunocytochemistry
Biochem/physiol Actions
Brain-derived neurotrophic factor (BDNF) is involved in hippocampal function and verbal episodic memory in humans. BDNF also plays a vital role in vascular function and participates in angiogenesis through the specific receptor tropomyosin-related kinase B (TrkB). Changes in BDNF expression have been extensively investigated in depression, drug addition, schizophrenia, bipolar and anxiety disorders, Huntington′s disease and Rett syndrome. In addition, BDNF is associated with Alzheimer′s disease (AD) and its reduced levels were detected in post-mortem brain tissues of AD patients. It can exert profound effects on development, morphology, synaptic plasticity and brain functions.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable