SAB4200746
抗α-甲胎蛋白(AFP)，小鼠单克隆抗体
clone C3, purified from hybridoma cell culture
别名:
抗-α-1-甲胎蛋白, 抗-α-甲胎蛋白, 抗-AFP
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关于此项目
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
C3, monoclonal
Application:
DB, ELISA, IF, IHC
Citations:
6
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
C3, monoclonal
form
buffered aqueous solution
mol wt
~74 kDa
species reactivity
human, canine, porcine
concentration
~1.0 mg/mL
technique(s)
ELISA: suitable, dot blot: suitable, immunoblotting: 2-4 μg/mL using liver hepatocellular carcinoma HepG2 cell line extract, immunofluorescence: suitable, immunohistochemistry: 2-4 μg/mL using formalin-fixed, paraffin-embedded human fetal liver sections
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AFP(174)
General description
编码α-肽蛋白（AFP）的基因定位于人4号染色体。它编码一种分子量为70kDa的血浆糖蛋白。在胚胎卵黄囊和肝脏发育过程中，它是与血清白蛋白一起合成的。
Immunogen
纯化的人α-肽蛋白
Biochem/physiol Actions
α-肽蛋白（AFP）可参与到胎儿和增生的成人肝细胞中脂肪酸的调节。在急性肝损伤中发现其表达有所提高，表明活跃的肝再生。AFP与脂肪肝疾病（FLD）相关，而这是一种可能导致肝硬化和肝细胞癌的疾病。它可作为HCC（肝细胞癌）的一种肿瘤标志物。
Physical form
溶于含有 15 mM 叠氮化钠的 0.01M 磷酸盐缓冲盐水（pH 7.4）溶液中。
Preparation Note
储存在–20°C。若需连续使用，可在2-8°C下储存最长一个月。若需延长储存时间，可将溶液分装并冷冻。不建议反复冻融。如果长期储存时出现轻微浑浊，请在使用前通过离心澄清溶液。若工作稀释样品在12小时内未使用完，则应丢弃。
Other Notes
为了在不同的技术和制备中获得最佳结果，我们建议通过效价测试确定最佳的工作浓度。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Linkage of the evolutionarily-related serum albumin and alpha-fetoprotein genes within q11-22 of human chromosome 4.
M E Harper, et al.
American Journal of Human Genetics (1983)
Evaluation of alpha-fetoprotein in detecting hepatocellular carcinoma recurrence after radiofrequency ablation.
Siripongsakun S, et al.
Journal of Gastroenterology and Hepatology (2014)
Clinical significance of elevated serum alpha-fetoprotein (AFP) level in acute viral hepatitis A (AHA).
Seo SI, et al.
Hepato-Gastroenterology (2013)
Ana Gil-Bona et al.
International journal of molecular sciences, 24(21) (2023-11-14)
Excess albumin in enamel is a characteristic of the prevalent developmental dental defect known as chalky teeth or molar hypomineralization (MH). This study uses proteomic analyses of pig teeth to discern between developmental origin and post-eruptive contamination and to assess
Association between serum alpha-fetoprotein levels and fatty liver disease: a cross-sectional study.
Xu P, et al.
World Journal of Gastrointestinal Oncology (2014)
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