SAB4200759
Anti-Human IgG3 antibody, Mouse monoclonal
clone HP-6050, purified from hybridoma cell culture
别名:
Anti-Immunoglobulin G3
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
HP-6050, monoclonal
Species reactivity:
human
Application:
ELISA (i), IP
Citations:
3
biological source
mouse
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
HP-6050, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 1-2.5 μg/test using Human IgG3 myeloma, indirect ELISA: 0.15-0.3 μg/mL using 1 μg/ml Human IgG3 myeloma for coating
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
General description
Human IgG consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5 and 4% of the total IgG, respectively. The abundance of the different IgG subclasses in the bloodstream varies with age, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels rise more slowly, reaching adult levels at about 10 years of age.
Immunogen
Human IgG3 myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads
Application
Anti-Human IgG3 antibody, mouse monoclonal has been used in indirect ELISA and immunoprecipitation.
Biochem/physiol Actions
IgG1 and IgG3 are the only subclasses capable of adherence to mononuclear phagocytes and are recognized readily by the Fc receptors on various reticulo-endothelial . IgG3 deficiency has been associated with a history of recurrent infectious, leading to chronic lung disease.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis.
Zhou, et al.
Cell Death & Disease, 14, 254-254 (2023)
R Jefferis et al.
Immunology letters, 10(3-4), 223-252 (1985-01-01)
Seventy-four monoclonal antibodies (McAb) of putative specificity for human IgG (11), the IgG sub-classes (59) or Gm allotypes (4) have been evaluated for reactivity and specificity in eight laboratories employing different assay techniques or protocols. For the IgG, IgG3, IgG4
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These
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