SAB4200814
Anti-TIMP2 antibody, Mouse monoclonal
clone TM8, purified from hybridoma cell culture
别名:
CSC-21K, Metalloproteinase inhibitor 2, Tissue inhibitor of metalloproteinases 2
产品名称
Anti-TIMP2 antibody, Mouse monoclonal, clone TM8, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
TM8, monoclonal
species reactivity
human
packaging
antibody small pack of 25 μL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1 mg/mL
technique(s)
immunoblotting: 0.5-1 μg/mL using HEK-293 over expressing human TIMP2 cells extract.
immunofluorescence: 2.5-5 μg/mL using human HeLa cells.
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TIMP2(7077)
Application
The antibody is recommended to use in various immunological techniques, including Immunoblot (~24 kDa) and immunofluorescence. Detection of the TIMP2 band by Immunoblotting is specifically inhibited by the immunogen.
Biochem/physiol Actions
"The MMPs activity inhibition is mediated directly by blocking the MMPs catalytic zinc ion with the TIMPs N-terminal cysteine residue.1-2 TIMP2 is also highly studied for it MMP-independent effects including cell cycle regulation 2-4 and its involvement in several cancers progression and invasiveness (e.g. renal cell carcinoma3, non-small cell lung cancer (NSCLC)5 and Gastric Cancer6).Due to the pronounced inhibitory activity, the TIMPs are considered as a potential target in designing new inhibitor variants with altered specificity for MMPs and other zinc-dependent extracellular matrix (ECM) proteins.1-2"
Monoclonal Anti-TIMP2 specifically recognizes human TIMP2.
Disclaimer
Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
TIMP2- Tissue Inhibitor of Metalloproteinases 2, also known as CSC-21K, is a member of the TIMP family of matrix metalloproteinases (MMPs) natural inhibitors. These proteins are involved in regulation of activated MMPs and in extracellular matrix degradation. the TIMPs family consists of 4 members which act in a non-selective manner.
Immunogen
Recombinant TIMP2 protein.
Physical form
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
Preparation Note
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持