SAB4300033
抗 磷酸化-STAT3 (pTyr 705 ) 兔抗
affinity isolated antibody
别名:
抗 FLJ20882 兔抗, 抗 HIES 兔抗, 抗 MGC16063 兔抗, 抗 信号转导子和转录激活子 3（急性期反应因子） 兔抗, 抗 APRF 兔抗
产品名称
抗 磷酸化-STAT3 (pTyr 705 ) 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~88 kDa
species reactivity
rat, mouse, human
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(A-P-YP-L-K)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr705)
Quality Level
Gene Information
human ... STAT3(6774)
Application
兔抗磷酸化STAT3 (pTyr705)抗体可用于免疫组织化学染色和免疫印迹。
Biochem/physiol Actions
信号转导与转录激活因子3（STAT3）在各种细胞反应中发挥着关键作用，比如在肝癌细胞诱导急性期反应、刺激B淋巴细胞增殖、激活单核细胞终末分化和生长停滞，以及调控胚胎干细胞的多能性。激活的STAT3参与恶性转化。 STAT3可能是多种人类癌症发病机制中的关键因子，这使得该分子成为新疗法的主要靶点。 磷酸酪氨酸残基705（Tyr705）Stat3可用作判断淋巴节阴性乳腺癌患者总生存期的潜在标志物。 磷酸化STAT3可能参与血管生成、抗凋亡和肿瘤进展。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完全放心地试用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多。
General description
与多种急性期蛋白基因启动子中识别的白细胞介素-6 (IL-6) 应答元件结合的转录因子。通过 IL31RA 由 IL31 激活。
信号传感器和转录激活因子3（STAT3）是STAT家族的成员，由770个氨基酸组成。编码该蛋白质的基因由24个外显子组成，在基因组DNA上延伸超过75170个碱基。STAT3定位于人染色体17q21.2上。 该蛋白质的特征在于保守的氨基末端结构域、DNA结合结构域、SH2结构域和羧基末端反式激活结构域。
Immunogen
根据蛋白 STAT3，酪氨酸 705 (A-P-Y (P)-L-K) 磷酸化位点周围的肽序列。
Physical form
溶于含有0.02％叠氮化钠和50%甘油的磷酸盐缓冲盐水
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
R Elkaim et al.
Journal of oral microbiology, 9(1), 1334503-1334503 (2017-07-28)
Periodontitis is an inflammatory disease induced by pathogenic bacteria such as
STAT3 single-nucleotide polymorphisms and STAT3 mutations associated with hyper-IgE syndrome are not responsible for increased serum IgE serum levels in asthma families.
Wjst M
European Journal of Human Genetics, 17, 352-356 (2009)
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNF?-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.
Kawada M
PLoS ONE, 10 (2015)
Manchao Zhang et al.
Molecular cancer therapeutics, 14(10), 2313-2320 (2015-08-01)
Epithelial-restricted with serine box (ESX), a member of the ETS transcription factor family, is elevated and regulates EGFR in head and neck squamous cell carcinoma (HNSCC). However, the molecular mechanisms that contribute to ESX dysregulation remain to be elucidated. In
Liyun Chen et al.
The Journal of clinical investigation, 133(15) (2023-06-06)
Patients with cancer who have high serum levels of squamous cell carcinoma antigen 1 (SCCA1, now referred to as SERPINB3) commonly experience treatment resistance and have a poor prognosis. Despite being a clinical biomarker, the modulation of SERPINB3 in tumor
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