SAB4300110
Anti-phospho-CDK2 (pThr160) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-cyclin-dependent kinase 2 antibody produced in rabbit, Anti-p33(CDK2) antibody produced in rabbit
产品名称
Anti-phospho-CDK2 (pThr160) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~34 kDa
species reactivity
rat, human, mouse
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(T-Y-TP-H-E)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pThr160)
Quality Level
Gene Information
human ... CDK2(1017)
Biochem/physiol Actions
Cyclin-dependent kinase 2 (CDK2) protein participates in the recombination and differentiation of the cell. It plays a major role in metabolism, apoptosis, senescence, and meiosis. CDK2 is involved in the development of embryos and the remodeling of chromatin. It also plays a key role in DNA damage and DNA damage response (DDR). CDK2 controls the progression of the cell cycle. Changes in the activity of CDK2 might have an impact on human carcinogenesis. Absence of CDK2 results in DNA damage and DDR activation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Cyclin-dependent kinase 2 (CDK2), a nucleus-cytoplasm trafficking protein, belongs to the cyclin-dependent kinase (CDK) family. The CDK2 gene is located on human chromosome 12q13.2.
Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.
Immunogen
Peptide sequence around phosphorylation site of threonine 160 (T-Y-T(p)-H-E), according to the protein CDK2.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
D J Demetrick et al.
Cytogenetics and cell genetics, 66(1), 72-74 (1994-01-01)
Cyclin dependent kinases (CDK's) are kinases that interact with cyclins and regulate cell division. Genomic clones encoding human CDK2, CDK4, and CDK5 were obtained and mapped to their respective chromosomal loci using fluorescence in situ hybridization on human lymphocyte metaphase
Qi Liu et al.
DNA repair, 85, 102702-102702 (2019-11-16)
CDK2 (cyclin-dependent kinase 2), a member of the CDK family, has been shown to play a role in many cellular activities including cell cycle progression, apoptosis and senescence. Recently, accumulating evidence indicates that CDK2 is involved in DNA damage and
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