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Merck
CN

SAB4300183

Anti-phospho-EGFR (pTyr1197) antibody produced in rabbit

affinity isolated antibody

别名:

Anti-ERBB antibody produced in rabbit, Anti-ERBB1 antibody produced in rabbit, Anti-HER1 antibody produced in rabbit, Anti-PIG61 antibody produced in rabbit, Anti-epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody produced in rabbit

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
western blot
Species reactivity:
mouse, human, rat
Citations:
1
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
Uniprot accession no.:
P00533

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产品名称

Anti-phospho-EGFR (pTyr1197) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~175 kDa

species reactivity

mouse, human, rat

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(A-E-YP-L-R)

NCBI accession no.

NP_005219.2

UniProt accession no.

P00533

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr1197)

Quality Level

100

Gene Information

human ... EGFR(1956)

相关类别

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 1197 (A-E-Y(p)-L-R), according to the protein EGFR.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
871511228

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Yu Yu et al.
EBioMedicine, 47, 184-194 (2019-09-08)
Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas, for which effective therapy is urgently needed. SYK phosphorylates several substrates, but their translational implications remain unclear. Here, we show that SYK interacts with EGFR and ERBB2, and directly

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