SAB4300254
Anti-phospho-NTRK1 (pSer791) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-DKFZp781I14186 antibody produced in rabbit, Anti-MTC antibody produced in rabbit, Anti-TRK antibody produced in rabbit, Anti-TRK1 antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 1 antibody produced in rabbit
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~140 kDa
种属反应性
mouse, human, rat
浓度
1 mg/mL
技术
indirect immunofluorescence: 1:100-1:200
同位素/亚型
IgG
免疫原序列
(P-V-YP-L-D)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer791)
基因信息
human ... NTRK1(4914)
一般描述
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
免疫原
Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D), according to the protein NTRK1.
特点和优势
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外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Deidiane Elisa Ribeiro et al.
Progress in neuro-psychopharmacology & biological psychiatry, 93, 232-239 (2019-04-17)
Nitric oxide (NO) triggers escape reactions in the dorsal periaqueductal gray matter (dPAG), a core structure mediating panic-associated response, and decreases the release of BDNF in vitro. BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects
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