SAB4300254
Anti-phospho-NTRK1 (pSer791) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-DKFZp781I14186 antibody produced in rabbit, Anti-MTC antibody produced in rabbit, Anti-TRK antibody produced in rabbit, Anti-TRK1 antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 1 antibody produced in rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~140 kDa
species reactivity
mouse, human, rat
concentration
1 mg/mL
technique(s)
indirect immunofluorescence: 1:100-1:200
isotype
IgG
immunogen sequence
(P-V-YP-L-D)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer791)
Gene Information
human ... NTRK1(4914)
General description
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Immunogen
Peptide sequence around phosphorylation site of tyrosine791 (P-V-Y(p)-L-D), according to the protein NTRK1.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Deidiane Elisa Ribeiro et al.
Progress in neuro-psychopharmacology & biological psychiatry, 93, 232-239 (2019-04-17)
Nitric oxide (NO) triggers escape reactions in the dorsal periaqueductal gray matter (dPAG), a core structure mediating panic-associated response, and decreases the release of BDNF in vitro. BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects
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