Anti-phospho-NTRK2 (pTyr⁷⁰⁵) antibody produced in rabbit

NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on chromosome 9q21.32 .

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R), according to the protein NTRK2.

Anti-phospho-NTRK2 (pTyr705) antibody has been used in western blotting.

In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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