Anti-EIF2AK2 (Ab-451) antibody produced in rabbit

EIF2AK2 (eukaryotic translation initiation factor 2α kinase 2) is an intracellular protein, that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2α family of protein kinases. It contains two RNA binding domains and a kinase domain. It is located on chromosome 2p22-p21.

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

Peptide sequence around aa. 449-453 (K-G-T-L-R), according to the protein EIF2AK2.

EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral response promoted by interferon. It is involved in stress response and inflammation pathways. It controls the development and multiplication of cell, nutrient signaling and metabolism. It also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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