SAB4300533
Anti-EIF2AK2 (Ab-451) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-EIF2AK1 antibody produced in rabbit, Anti-MGC126524 antibody produced in rabbit, Anti-PKR antibody produced in rabbit, Anti-PRKR antibody produced in rabbit, Anti-eukaryotic translation initiation factor 2-alpha kinase 2 antibody produced in rabbit
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC (p)
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~74 kDa
species reactivity
human
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200
isotype
IgG
immunogen sequence
(K-G-T-L-R)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EIF2AK2(5610)
General description
EIF2AK2 (eukaryotic translation initiation factor 2α kinase 2) is an intracellular protein, that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2α family of protein kinases. It contains two RNA binding domains and a kinase domain. It is located on chromosome 2p22-p21.
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
Immunogen
Peptide sequence around aa. 449-453 (K-G-T-L-R), according to the protein EIF2AK2.
Biochem/physiol Actions
EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral response promoted by interferon. It is involved in stress response and inflammation pathways. It controls the development and multiplication of cell, nutrient signaling and metabolism. It also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Regulation of PKR by RNA: formation of active and inactive dimers
Husain B, et al.
Biochemistry, 54(44), 6663-6672 (2015)
Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease
Varghese GP, et al.
Molecular Medicine Reports, 11(6), 4579-4584 (2015)
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