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所有图片(1)
别名:
Anti-KIAA0403 antibody produced in rabbit, Anti-MOR antibody produced in rabbit, Anti-MOR1 antibody produced in rabbit, Anti-OPRM antibody produced in rabbit, Anti-opioid receptor, mu 1 antibody produced in rabbit
NACRES:
NA.41
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
~80 kDa
种属反应性
mouse, rat
浓度
1 mg/mL
技术
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(H-P-S-T-A)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... OPRM1(4988)
一般描述
The gene OPRM1 (opioid receptor μ 1) is mapped to human chromosome 6q24-q25. The gene spans a length of 200kb and contains 11 exons that yield 17 splice variants.
免疫原
Peptide sequence around aa. 373-377 (H-P-S-T-A), according to the protein OPRM1.
应用
Anti-OPRM1 (Ab-375) antibody produced in rabbit has been used in Western blotting.
生化/生理作用
The gene OPRM1 (opioid receptor μ 1) encodes a μ opioid receptor that functions in pain perception and addiction to drugs of abuse, such as cocaine, nicotine and alcohol. It serves as a target for opioid drugs, such as morphine, methadone and heroin and opioid peptides (like β - endorphin and endomorphins) and mediates their effects. Single nucleotide polymorphism in the OPRM1 gene is associated with an inclination to drug addiction and lesser response to painful stimuli.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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示例
T1503
货号
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25G
包装规格/数量
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Association of time-dependent changes in μ opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving.
Theberge FR, et al.
Psychopharmacology (Psychopharmacologia), 224(4), 559-571 (2012)
Jörn Lötsch et al.
Anesthesiology, 97(4), 814-819 (2002-10-03)
Some, but not all, patients with renal dysfunction suffer from side effects after morphine administration because of accumulation of the active metabolite morphine-6-glucuronide (M6G). The current study aims to identify genetic causes that put patients at risk for, or protect
Shinya Kasai et al.
Pharmacogenomics, 12(9), 1305-1320 (2011-09-17)
The µ-opioid receptor is a primary target for clinically important opioid analgesics, including morphine, fentanyl and methadone. Many genetic variations have been identified in the human µ-opioid receptor MOP gene (OPRM1), and their implications have been reported in the effects
Raymond F Anton et al.
Archives of general psychiatry, 65(2), 135-144 (2008-02-06)
Naltrexone hydrochloride treatment for alcohol dependence works for some individuals but not for everyone. Asn40Asp, a functional polymorphism of the mu-opioid receptor gene (OPRM1), might predict naltrexone response. To evaluate whether individuals with alcoholism who are heterozygous (Asp40/Asn40) or homozygous
Florence R M Theberge et al.
Psychopharmacology, 224(4), 559-571 (2012-07-14)
Responding to heroin cues progressively increases after cessation of heroin self-administration (incubation of heroin craving). We investigated whether this incubation is associated with time-dependent changes in brain-derived neurotrophic factor (BDNF) and methyl-CpG binding protein 2 (MeCP2) signaling and mu opioid
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