SAB4300572
Anti-TRPC6 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-FLJ11098 antibody produced in rabbit, Anti-FLJ14863 antibody produced in rabbit, Anti-FSGS2 antibody produced in rabbit, Anti-TRP6 antibody produced in rabbit, Anti-transient receptor potential cation channel, subfamily C, member 6 antibody produced in rabbit
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Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human, mouse, rat
Citations:
3
Technique(s):
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
Anti-TRPC6 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~100 kDa
species reactivity
human, mouse, rat
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(Q-D-Y-L-L)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TRPC6(7225)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Immunogen
peptide Corresponding to the amino terminal sequence from mouse TRPC6 protein , according to the protein TRPC6.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Natalie Youssef et al.
Biomedicines, 9(10) (2021-10-24)
Diabetic kidney disease (DKD), a serious diabetic complication, results in podocyte loss and proteinuria through NADPH oxidases (NOX)-mediated ROS production. DUOX1 and 2 are NOX enzymes that require calcium for their activation which enters renal cells through the pivotal TRPC
Jun Wu et al.
Journal of Huntington's disease, 7(1), 35-50 (2018-02-27)
Huntington disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. We previously discovered that mutant Huntingtin sensitizes type 1 inositol 1,4,5-trisphosphate receptor (InsP3R1) to InsP3. This causes calcium leakage from the
Hua Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(47), 11837-11850 (2016-11-25)
Mushroom dendritic spine structures are essential for memory storage and the loss of mushroom spines may explain memory defects in aging and Alzheimer's disease (AD). The stability of mushroom spines depends on stromal interaction molecule 2 (STIM2)-mediated neuronal-store-operated Ca2+ influx
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