SAB4300587
Anti-JAK2 (Ab-570) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-JTK10 antibody produced in rabbit, Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~125 kDa
种属反应性
rat, human
浓度
1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
同位素/亚型
IgG
免疫原序列
(G-D-Y-G-Q)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... JAK2(3717)
一般描述
JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of protein. It is located on chromosome 9p24.
Plays a role in leptin signaling and control of body weight.
免疫原
Peptide sequence around aa. 568-572 (G-D-Y-G-Q), according to the protein JAK2.
生化/生理作用
JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.
特点和优势
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外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2
Joos S, et al.
International Journal of Cancer. Journal International Du Cancer, 103(4), 489-495 (2003)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Borriello L
Cancer Research, 77(18), 5142-5157 (2017)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)
Jak2 is essential for signaling through a variety of cytokine receptors
Parganas E, et al.
Cell, 93(3), 385-395 (1998)
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