Anti-CD44 antibody produced in rabbit

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

The CD44 (cell-surface glycoprotein) gene encodes a transmembrane glycoprotein, and has 20 exon. It is mapped to human chromosome 11p13.

The antibody detects endogenous level of total CD44 protein.

Peptide sequence around aa. 734-738 (Q-N-V-D-M), according to the protein NP_000601.3

Overexpression of CD44 (cell-surface glycoprotein) leads to esophageal squamous cell carcinoma (ESCC). It is involved in cell-cell and cell-extracellular matrix interactions. It plays an important role in lymphocyte homing and lymphocyte activation. It also acts as a metastasis suppressor gene for prostatic cancer.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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