biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
55 kDa
species reactivity
rat, mouse, human
concentration
2.8 mg/mL
technique(s)
immunohistochemistry: 1:50- 1:200, western blot: 1:500-1:2000 (Cell Lysate)
isotype
IgG
accession no.
NP_036211.2
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DGAT1(8694)
General description
Diacylglycerol-acyltransferase 1 (DGAT1), a transmembrane protein, is a member of the membrane-bound O-acyltransferase superfamily. It is seen in the endoplasmic reticulum of several cells. DGAT1 is ubiquitously expressed in humans. A high level of mRNA is seen in the small intestine. It has three transmembrane domains. The DGAT1 gene is mapped to human chromosome 8q24.3.
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human diacylglycerol O-acyltransferase 1
Application
Anti-DGAT1 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Diacylglycerol-acyltransferase 1 (DGAT1) converts diacylglycerol and fatty acyl-CoA to triacylglycerol. It participates in energy storage. DGAT1 plays a key role in cancer progression. Activity of DGAT1 is essential for the physiologic absorption of vitamin D. Absence of DGAT1 activity is linked with body weight and adiposity reduction, and increased insulin sensitivity. Aberrations in the DGAT1 gene are associated with congenital diarrheal disorder (CDD).
The antibody detects endogenous levels of total DGAT1 protein.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Ping He et al.
BMC cancer, 21(1), 252-252 (2021-03-23)
Diacylglycerol-acyltransferase 1 (DGAT1) plays an important role in the energy storage and is involved in cancer progression. A growing number of evidences showed that elevated expression of DGAT1 in cancer tissue indicated a poor outcome in cancer patients. However, the
Aditi Gupta et al.
European journal of medical genetics, 63(4), 103817-103817 (2019-11-30)
DGAT1, a gene encoding a protein involved in lipid metabolism, has been recently implicated in causing a rare nutritional and digestive disease presenting as Congenital Diarrheal Disorder (CDD). Genetic causes of malnutrition can be classified as metabolic disorders, caused by
A Mercadé et al.
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 122(3), 161-164 (2005-09-01)
DGAT1 is a microsomal enzyme that catalyses the final step in triglycerides synthesis. DGAT1-deficient mice are viable, lean, fertile and resistant to diet induced obesity. We have previously identified a quantitative trait loci (QTL) on chromosome 4 that affects fatty
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4301075-100UL | 04061837446764 |