产品名称
Anti-RAS antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
21 kDa
species reactivity
mouse, rat, human
concentration
0.7 mg/mL
technique(s)
western blot: 1:200-1:1000 (Cell Lysate)
isotype
IgG
accession no.
NP_001123914.1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HRAS(3265)
Biochem/physiol Actions
Ras is a guanine-nucleotide binding protein that couples tyrosine kinase receptor signals to mitogen activated protein (MAP) kinase cascade. It has an important role in cell growth. Ras is a substrate for farnesyltransferase (FTase) and when farnesylated, it is anchored to the membrane. Membrane localization of Ras is crucial for its cellular activity. Inhibition of Ras farnesylation is a target for anti-cancer drug development.
The antibody detects endogenous level of total RAS protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Ras is a proto-oncogene and the gene encoding it is localized on human chromosome 11p15.5. It is a 21 kDa protein and is part of the small GTP-binding proteins superfamily.
Immunogen
Synthetic peptide corresponding to a region derived from 60-74 amino acids of Human v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Physical form
Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat structural evidence for a 11p15. 5 gene family.
Desseyn J L, et al.
The Journal of Biological Chemistry, 272(6), 3168-3178 (1997)
Germline mutations in HRAS proto-oncogene cause Costello syndrome.
Aoki Y, et al.
Nature Genetics, 37(10), 1038-1038 (2005)
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.
Rowinsky E K, et al.
Journal of Clinical Oncology, 7(11), 3631-3652 (1999)
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