Anti-phospho-BLK (pTyr⁵⁰¹) antibody produced in rabbit

B lymphoid tyrosine kinase (BLK) protein belongs to the Src kinase family. It has an Src homology 3 (SH3) and an Src homology 2 (SH2) domain N-terminal to the catalytic kinase domain. The BLK gene is located on human chromosome 8p23.1.

The antibody detects endogenous levels of BLK only when phosphorylated at tyrosine 501.

Peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y(p)-E-L) derived from Human BLK.

B lymphoid tyrosine kinase (BLK) protein has oncogenic properties. It helps B-cell receptors transmit signals and may be important for B-cell repertoire development and mature B-cell activity. BLK participates in B-cell antigen receptor signaling. The BLK gene polymorphisms are linked to renal dysfunction in people with systemic lupus erythematosus.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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