产品名称
Anti-YAP antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 48 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... YAP1(10413)
Biochem/physiol Actions
Yes associated protein (YAP) serves as a potent mechanosensitive transcriptional activator. It plays a vital role in regulation of cancer, regeneration and organ size. Overexpression of the gene contributes to tumorigenesis in breast and liver cancers. In addition, it also promotes gallbladder cancer (GBC) cell growth via activating AXL receptor tyrosine kinase/mitogen-activated protein kinase (MAPK) pathway. Thus, it acts as a potent biomarker and therapeutic target for various cancers including, GBC and breast cancer.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-YAP Antibody detects endogenous levels of total YAP protein.
Yes associated protein (YAP) is a 65kDa proline-rich phosphoprotein. It is encoded by the gene mapped to human chromosome 11q22.1. The encoded protein is characterized with a WW domain, a PDZ interaction motif, an SH3 binding motif and a coiled-coil domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human YAP.
Immunogen Range: 93-142
Immunogen Range: 93-142
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.
Elosegui-Artola A, et al.
Cell, 171(6), 1397-1410 (2017)
Expression of YES-associated protein (YAP) and its clinical significance in breast cancer tissues.
Cao L, et al.
Human Pathology, 68, 166-174 (2017)
Yes-Associated Protein 1 Exhibits Oncogenic Property in Gastric Cancer and Its Nuclear Accumulation Associates with Poor Prognosis
Kang W, et al.
Clinical Cancer Research, 17(8), 2130-2139 (2011)
Maolan Li et al.
Cancer letters, 355(2), 201-209 (2014-09-15)
The transcriptional coactivator Yes-associated protein 1 (YAP1), a key regulator of cell proliferation and organ size in vertebrates, has been implicated in various malignancies. However, little is known about the expression and biological function of YAP1 in human gallbladder cancer
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