SAB4500131
Anti-TRXR2 antibody produced in rabbit
affinity isolated antibody
别名:
Selenoprotein Z, TR-β, Thioredoxin reductase 2, Thioredoxin reductase TR3
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 56 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TXNRD2(10587)
General description
Anti-TRXR2 Antibody detects endogenous levels of total TRXR2 protein.
Thioredoxin reductase 2 (TRXR2) is mitochondrial protein-disulfide oxidoreductase, encoded by the gene mapped to human chromosome 22q11.21. TRXR2 is one of the mammalian isoforms of thioredoxin reductase (TrxR).
Immunogen
The antiserum was produced against synthesized peptide derived from human TRXR2.
Immunogen Range: 471-520
Immunogen Range: 471-520
Biochem/physiol Actions
Thioredoxin reductase 2 (TRXR2) regulates cell survival during mammalian embryonic development. In addition, it also regulates mitochondria-dependent apoptosis. TRXR2 also controls protein tyrosine phosphorylation and cell proliferation. The protein expression is associated with development of glioma. In humans, this enzyme stimulates the apoptosis in HeLa cells. Mutation in the gene might increase the risk of susceptibility to myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) patients.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus
Kariz S, et al.
Diabetes Research and Clinical Practice, 108(2), 323-328 (2015)
Mitochondrial thioredoxin system effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis.
Patenaude A, et al.
The Journal of Biological Chemistry, 279(26), 27302-27314 (2004)
The Genes Associated with RNA Editing and Glioma on the Chromosome 22q.
Wang G and Tian Y
Advances in Medical Sciences, 2(1) (2014)
Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation
Kim MR, et al.
Biochemical and Biophysical Research Communications, 304(1), 119-124 (2003)
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