产品名称
Anti-Histone H3 (Acetyl-Lys18) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 15 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
acetylation (Lys18)
Quality Level
Gene Information
human ... HIST1H3A(8350)
Application
Anti-Histone H3 (Acetyl-Lys18) antibody has been used in enzyme-linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Histone proteins are basic building blocks of chromatin. Mutations in Histone H3 results in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that “drive” chromatin condensation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-Histone H3 (Acetyl-Lys18) Antibody detects endogenous levels of total Histone H3 (Acetyl-Lys18) protein.
Histone H3 is located on chromosome 6p22. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A).
Immunogen
The antiserum was produced against synthesized peptide derived from human Histone H3 around the acetylated site of Lys18.
Immunogen Range: 1-50
Immunogen Range: 1-50
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and-independent acetylation-mediated mechanisms in memory formation.
Merschbaecher K, et al.
Learning & Memory, 23(2), 83-89 (2016)
Katja Merschbaecher et al.
Learning & memory (Cold Spring Harbor, N.Y.), 23(2), 83-89 (2016-01-17)
Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive
Signaling to chromatin through histone modifications.
Cheung P, et al.
Cell, 103(2), 263-271 (2000)
Histone H3 K27M mutations in adult cerebellar high-grade gliomas.
Nakata S, et al.
Brain Tumor Pathology, 34(3), 113-119 (2017)
The program for processing newly synthesized histones H3.1 and H4.
Campos EI
Nature Structural and Molecular Biology, 17(11), 1343-1351 (2010)
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