产品名称
Anti-Collagen I α2 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 129 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL1A2(1278)
Application
Anti-Collagen I α2 antibody has been used to quantify protein expression levels after western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Collagen I α2 (COL1A2) is essential to maintain elasticity of the vessel wall and is an important constituent of the extracellular matrix. Mutations in COL1A2 results in osteogenesis imperfecta (OI).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-Collagen I α2 Antibody detects endogenous levels of total Collagen I α2 protein.
Collagen I α2 (COL1A2) is located on human chromosome 7q22.1. Human COL1A2 gene consists of two dinucleotide repeats: one in the 5′-flanking region of the gene, made of of poly(dC–dA) and poly(dC–dG) and the other in the first intron comprised of poly(dG–dT).
Immunogen
The antiserum was produced against synthesized peptide derived from human Collagen I alpha2.
Immunogen Range: 471-520
Immunogen Range: 471-520
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Collagen type I ?2 (COL1A2) is the susceptible gene for intracranial aneurysms.
Yoneyama T, et al.
Stroke, 35(2), 443-448 (2004)
Transcriptional regulation of the human type I collagen ?2 (COL1A2) gene by the combination of two dinucleotide repeats.
Akai J, et al.
Gene, 239(1), 65-73 (1999)
Angiotensin II increases fibronectin and collagen I through the ?-catenin-dependent signaling in mouse collecting duct cells.
Cuevas CA, et al.
American Journal of Physiology: Renal Physiology, 308(4), F358-F365 (2014)
Jianhui Xu et al.
Proteomics. Clinical applications, 14(4), e1900112-e1900112 (2020-03-12)
Cystic vestibular schwannoma (CVS) and solid vestibular schwannoma (SVS) are subgroups of vestibular schwannoma (VS). The tumorigenesis of CVS and SVS have not been fully elucidated, and this study is designed to identify differentially expressed proteins involved in the tumorigenesis
Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population.
Tian DZ, et al.
Genetics and molecular research : GMR, 15(1) (2015)
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