SAB4500412
Anti-COX41 antibody produced in rabbit
affinity isolated antibody
别名:
COX IV-1, COX4, COXIV, cytochrome c oxidase polypeptide IV
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
human
Citations:
3
Technique(s):
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
Anti-COX41 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 19 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COX4I1(1327)
Biochem/physiol Actions
COX4 isoform 1 (COX4-1) (COX4-1) may play an important role in glioma chemoresistance. It regulates the upregulation of BMI1 (polycomb complex protein BMI1). It is necessary for the multiplication of GBM (glioblastoma multiforme). In cells, expression of COX4-1 is necessary to maintain the stability of mitochondria and ROS (reactive oxygen species) homeostasis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Anti-COX41 Antibody detects endogenous levels of total COX41 protein.
COX41 (cytochrome c oxidase subunit 4I1) is located on human chromosome 16q24. COX4NB (COX4 neighbour) and COX4I1 (COX4 isoform 1) belongs to the cytochrome C oxidase subunit IV (COX4) family.
Immunogen
The antiserum was produced against synthesized peptide derived from human COX41.
Immunogen Range: 11-60
Immunogen Range: 11-60
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A small de novo 16q24.1 duplication in a woman with severe clinical features
Quemener-Redon S, et al.
European Journal of Medical Genetics, 56(4), 211-215 (2013)
Fan Yang et al.
Journal of cellular biochemistry, 119(2), 2427-2439 (2017-09-16)
Mitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR-410, was previously reported to be dynamically regulated
Claudia R Oliva et al.
Oncotarget, 6(6), 4330-4344 (2015-03-03)
Nuclear-encoded cytochrome c oxidase subunit 4 (COX4) is a key regulatory subunit of mammalian cytochrome c oxidase, and recent studies have demonstrated that COX4 isoform 1 (COX4-1) could have a role in glioma chemoresistance. The Polycomb complex protein BMI1 is
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