SAB4500466
Anti-CRHR2 antibody produced in rabbit
affinity isolated antibody
别名:
CRF-R 2, CRF2, CRH-R 2, Corticotropin-releasing factor receptor 2, Corticotropin-releasing hormone receptor 2
产品名称
Anti-CRHR2 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 47 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CRHR2(1395)
Application
Anti-CRHR2 antibody has been used in immunoprecipitation and western blotting .{6,7}
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
CRHR2 (corticotropin releasing hormone receptor 2) is involved in the relaxation of smooth muscle response and may affect the response of acute airway bronchodilator to short acting β2 agonist treatment of asthma. Signaling pathways of CRHR2 modulate the hypothalamic-pituitary-adrenocortical axis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-CRHR2 antibody detects endogenous levels of total CRHR2 protein.
The CRHR2 (corticotropin releasing hormone receptor 2) gene is a member of G protein coupled receptors (GPCRs) family. It is located on human chromosome 7p21-p15. It has 12 exons and approximately 50,000 base pairs (Kbp). It has 3 isoforms, such as CRHR2α β and γ out of which, CRHR2γ is mostly expressed in the brain and CRHR2α 2β are expressed in the brain and smooth muscle.
Immunogen
The antiserum was produced against synthesized peptide derived from human CRHR2.
Immunogen Range: 71-120
Immunogen Range: 71-120
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma
Poon AH, et al.
Pharmacogenetics and Genomics, 18, 373-382 (2008)
Katalin Eszter Ibos et al.
Pflugers Archiv : European journal of physiology, 476(2), 179-196 (2023-11-22)
Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study was to assess the effect of moderate CKD on anxiety in rats. 5/6 nephrectomy was performed in
N Y Intekhab-Alam et al.
Cell death & disease, 4, e717-e717 (2013-07-13)
Osteoarthritis (OA) is characterized by a loss of joint mobility and pain resulting from progressive destruction and loss of articular cartilage secondary to chondrocyte death and/ or senescence. Certain stimuli including nitric oxide (NO) and the pro-inflammatory cytokine tumor necrosis
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