SAB4500475
Anti-NEK7 antibody produced in rabbit
affinity isolated antibody
别名:
NEK7, NimA-related protein kinase 7, Serine/threonine-protein kinase Nek7
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 34 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NEK7(140609)
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General description
NIMA-related Kinase 7/never in mitosis A-related kinase 7 (NEK7), a serine/threonine kinase belongs to the NIMA-related protein kinase (NEK) family. It is the smallest NIMA-related kinase (NEK) protein seen in mammals, which is made up of a catalytic domain with a 30–40 amino acid N-terminal extension. NEK7 is abundantly expressed in the heart, liver, testis, lung, muscle, brain, spleen, and leukocyte. The NEK7 gene is located on human chromosome 1.
Immunogen
The antiserum was produced against synthesized peptide derived from human NEK7.
Immunogen Range: 101-150
Immunogen Range: 101-150
Biochem/physiol Actions
NIMA-related Kinase 7/never in mitosis A-related kinase 7 (NEK7) is essential to form procentriole. It participates in regulating the cell cycle. In addition to the pathological and physiological effects, NEK7 is also involved in the formation of the spindle during mitosis. It is expressed at a high level in gallbladder cancer. NEK7 controls cytokinesis and stability of the microtubule. It can activate the spindle assembly checkpoint. NEK7 might also be associated with hepatocellular carcinoma (HCC).
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Zhenzhen Sun et al.
Frontiers in physiology, 11, 606996-606996 (2020-12-29)
NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and physiological roles of NEK7 have been widely reported in many studies. To date, the major function of NEK7 has been well documented in mitosis and NLRP3 inflammasome activation
Lei Zhou et al.
Oncotarget, 7(14), 18620-18630 (2016-02-28)
NIMA-related kinase-7 (Nek7) is a serine/threonine kinase involved in cell-cycle progression via mitotic spindle formation and cytokinesis. In this study, we investigated whether Nek7 involves in hepatocellular carcinoma (HCC). Interestingly, we found that Nek7 was significantly overexpressed in HCC than
Akshari Gupta et al.
Molecular biology of the cell, 28(15), 2123-2134 (2017-05-26)
The decision to commit to the cell cycle is made during G1 through the concerted action of various cyclin-CDK complexes. Not only DNA replication, but also centriole duplication is initiated as cells enter the S-phase. The NIMA-related kinase NEK7 is
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