SAB4500487
Anti-PARP (Cleaved-Asp214) antibody produced in rabbit
affinity isolated antibody
别名:
ADP-ribosyltransferase 1, ADPRT, ADPRT1, PARP, pADPRT-1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
12
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 24 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
proteolytically cleaved (Asp214)
Quality Level
Gene Information
human ... PARP1(142)
General description
Anti-PARP (Cleaved-Asp214) Antibody detects endogenous levels of fragment of activated PARP (Cleaved-Asp214) protein.
PARP1 (poly (ADP-ribose) polymerase 1) is a nuclear protein that consists of three functional domains. It belongs to the PARP family. It is located on chromosome 1q42.
Immunogen
The antiserum was produced against synthesized peptide derived from human PARP.
Immunogen Range: 165-214
Immunogen Range: 165-214
Application
Anti-PARP (Cleaved-Asp214) antibody has been used in Western Blotting.
Biochem/physiol Actions
PARP1 (poly (ADP-ribose) polymerase 1) participates in DNA repair. It serves as a facilitator of homologous recombination. It controls transcription by regulating chromatin structure, altering DNA methylation patterns, acting as a co-regulator of transcription factors and interacting with chromatin insulators. It also plays an important role in the protection of cardiovascular system.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
PARP-1 protein expression in glioblastoma multiforme
Galia A, et al.
European Journal of Histochemistry, 56 (2012)
Huajun Xi et al.
Molecular medicine reports, 24(3) (2021-07-20)
Forkhead‑box gene 1 (FOXG1) has been reported to serve an important role in various malignancies, but its effects on nasopharyngeal cancer (NPC) remain unknown. Thus, the present study aimed to investigate the specific regulatory relationship between FOXG1 and NPC progression. Tumor tissues and
PARP inhibition: PARP1 and beyond
Rouleau M, et al.
Nature Reviews. Cancer, 10 (2010)
Loss of ?(E)-catenin potentiates cisplatin-induced nephrotoxicity via increasing apoptosis in renal tubular epithelial cells
Wang X, et al.
Toxicological Sciences, 141 (2014)
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
Murai J, et al.
Cancer Research, 72 (2012)
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