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安全信息

SAB4500577

Sigma-Aldrich

Anti-ADRB2 antibody produced in rabbit

affinity isolated antibody

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别名:
ADRBR, B2AR, BAR, BETA2AR, β-2 adrenergic receptor, β-2 adrenoceptor, β-2 adrenoreceptor, ADRB2, ADRB2R
NACRES:
NA.41

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

antigen 46 kDa

种属反应性

human, rat, mouse

浓度

~1 mg/mL

技术

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... ADRB2(154)

一般描述

Anti-ADRB2 Antibody detects endogenous levels of total ADRB2 protein.
Adrenoceptor β 2/β2 adrenergic receptor (ADRB2), a transmembrane protein, belongs to the superfamily of G-protein coupled receptors (GPCRs). This protein is expressed in skeletal muscle, mast cells, lymphocytes, airway smooth muscle, epithelial and endothelial cells of the lung, the smooth muscle of blood vessels, oral and skin keratinocytes. It comprises seven transmembrane domains and three extracellular and three intracellular loops. ADRB2 gene is located on human chromosome 5q32. Anti-ADRB2 Antibody detects endogenous levels of total ADRB2 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human ADRB2.

Immunogen Range: 201-250

生化/生理作用

Adrenoceptor β 2/β2 adrenergic receptor (ADRB2) binding to agonist activates Gs protein. Variation in the ADRB2 gene is involved in blood pressure (BP) and body mass index (BMI). ADRB2 is associated with nasopharyngeal carcinoma.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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S Takami et al.
The American journal of physiology, 276(4), H1379-H1384 (1999-04-13)
Glucocorticoids and catecholamines exert important effects on cardiovascular physiology and metabolism. Variants of the glucocorticoid receptor gene (GRL) and the beta2-adrenergic receptor gene (ADRB2) have been associated with high blood pressure and obesity. These genes are close on human chromosome
ADRB2 (adrenoceptor beta 2, surface)
Oliveira DT and Calderon DMB
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2021)

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