SAB4500675
抗 MKP1 兔抗
affinity isolated antibody
别名:
3CH134, CL100, DUS1, Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1
产品名称
抗 MKP1 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 39 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DUSP1(1843)
Biochem/physiol Actions
In mast cells, MKP1 (mitogen-activated protein kinase phosphatase 1) blocks the functions of extracellular signal-regulated kinase (Erk)‐1/2 by glucocorticoid. It controls axon branching promoted by BDNF (brain-derived neurotrophic factor).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-MKP1 Antibody detects endogenous levels of total MKP1 protein.
MKP1 (mitogen-activated protein kinase phosphatase 1)/DUSP1 (dual specificity phosphatase 1) is a dual specificity phosphatase. It is also called as CL100, 3CH134 and Erp. MKP1 is located in the nucleus and is expressed in several tissues. It is located on human chromosome 5q35.
Immunogen
The antiserum was produced against synthesized peptide derived from human MKP1.
Immunogen Range: 318-367
Immunogen Range: 318-367
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells
Franklin CC and Kraft AS
The Journal of Biological Chemistry, 272(27), 272(27)-272(27) (1997)
MAP kinase phosphatases
Theodosiou A and Ashworth A
Genome Biology, 3(7) (2002)
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching
Jeanneteau F, et al.
Nature Neuroscience, 13(11), 1373-1379 (2010)
Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1
Kassel O, et al.
The Embo Journal, 20(24), 7108-7116 (2001)
Y Chu et al.
The Journal of biological chemistry, 271(11), 6497-6501 (1996-03-15)
Mitogen-activated protein (MAP) kinases can be grouped into three structural families, ERK, JNK, and p38, which are thought to carry out unique functions within cells. We demonstrate that ERK, JNK, and p38 are activated by distinct combinations of stimuli in
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